Metabolics Report

The Metabolics Report transforms our understanding of how genes confer metabolic individuality and that underpin energy regulation, healthspan and longevity

Metabolism refers to all cellular chemical reactions and is essential for life. It involves many interconnected pathways that can be divided into ‘anabolism’ (‘build up’ e.g., synthesis of sugars, fats, proteins and nucleic acids) and 'catabolism' (‘break down’ e.g., to release energy in the form of ATP). These complex processes, and the balance between them, are the key to energy metabolism and healthy cell structure and function

All living organisms take in nutrients to support metabolism and so key functions like energy production, growth, and development. Feeding behaviour (appetite), timing, amount and composition of that nutrition (proteins, fats, carbohydrates) has a large influence on metabolism. In recent decades, many populations have experienced increased availability of high calorie/low fibre, processed foods, which alongside decreased physical activity have contributed to metabolic dysfunction, and potentially metabolic syndrome. Indeed, over a billion people, about a quarter of the world's population, is now affected by MetS – characterised by abdominal obesity, insulin resistance, hypertension and hyperlipidemia; which can lead to type 2 diabetes, cardiovascular and neurodegenerative diseases and cancer.

Organisms should also be able to adapt their metabolism according to challenges such as excess/scarcity of nutrients, availability of substrates for energy, hot cold/ temperature, increased or reduced need for energy in certain contexts, increased or decreased need for growth and repair, modulation of  inflammation etc. Efficient metabolic systems and ‘metabolic flexibility’ are vital to enabling good energy and mental functioning, as well as protecting cells from undue damage and dysfunction, leading to chronic disease. 

This comprehensive report presents genes that most powerfully influence key pathways driving human metabolism. It incorporates over 40 genes and 50 SNPs across 6 pathways, including appetite regulation, nutrient sensing, sugar and fat metabolism, cholesterol and bile, and mitochondria and inflammation. These aspects of metabolism are foundational to what it means to be healthy in every way, so anyone and everyone can benefit from its detailed insights, in particular for:

  • Appetite dysregulation - under or overeating, emotional eating, obesity
  • Blood sugar imbalance - insulin resistance, diabetes
  • Optimising & personalising diet - is a ketogenic or paleo diet right for me
  • Digestive and liver detox issues - bile production, NAFLD
  • Mitochondrial damage - oxidative stress and inflammation
  • Low energy/ fatigue - CFS, long COVID, sports performance
  • Cardiovascular disease - raised triglycerides, cholesterol imbalance
  • Improving cognitive function - brain fog, neurodegenerative conditions

However the Metabolics report is not just for those with specific conditions or diseases, it is important to health for all. Understanding how these genes impact metabolic function enables us to optimise cellular health in general, and so  maximise health throughout our lifetimes, improving longevity and ‘healthspan’, the period of life we spend in good health, free from chronic disease. It is a great adjunct to the methylation, nutrient core and nervous reports.

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