Oral Contraceptive Pill
The oral contraceptive pill (OCP) depletes B6 and B12.
Mental Health
OCP may impact (deplete) many neurotransmitter pathways too.
It depends also on which OCP - some women have a sensitivity to progestin, which may impact their mood - particularly if GABA is vulnerable.
Lifecode Gx Reports
The
Oestrogen Balance Report would be useful - to balance hormones (similar to blood sugar/ dopamine etc - gentle modulations rather that volatility).
The report includes genes that impact synthesis - especially CYP17A1 and 19A1, and removal (so you have COMT in the Nervous System anyway), but the phase 2 is useful - especially UGT is useful as often gut reabsorption of oestrogens is a problem.