Vitiligo involves loss of skin pigmentation. It is thought to be an autoimmune condition. There are a range of genetic risk factors, many of which are in common with AITD (thyroid). In particular the CTLA4 and PTPN22 genetic variances are strongly associated with Vitiligo. Unsurprisingly optimisation of Vitamin D levels can be helpful.

Lifecode Gx Reports

We recommend the Thyroid Balance Report  as it also examines genes that confer susceptibility to inflammation and autoimmunity.

Genes included:  

- HPT Axis: CAPZB, FKBP5, GPX1*, PDE8B, TG*, TSHR* (*also involved in autoimmunity)

- Autoimmune: CTLA4, FOXE1, HLA-DQA1, HLA-DQB1 and PTPN22

- Inflammation: CD40, FCRL3, IL6, TNF, GC and VDR

Source (autoimmune -  - CTLA4, PTPN22) (autoimmune - CTLA4, PTPN22) (Vitamin D - DBP*, VDR) (*note DBP=VDBP=GC gene)

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